Howard Hawks had known a real-life flier who once parachuted from a burning plane. His co-pilot died in the ensuing crash and his fellow pilots shunned him for the rest of his life.
"Calling Barranca" later became a recurring line in Looney Toons/Merrie Melodies cartoons.
Richard Barthelmess had deep facial scars that resulted from an infection due to plastic surgery. The only way to cover them up was with heavy make-up, but Howard Hawks convinced him to leave them the way they were because "those scars tell the story and are important to your character." Hawks also removed planks to make Barthelmess appear smaller, to reflect his character's inferiority among his fellow pilots.
For the role of Judy MacPherson, Howard Hawks screen-tested Dorothy Comingore, Rochelle Hudson and Rita Hayworth. He selected Hayworth because she had a face "that the camera likes."
Howard Hawks and Jean Arthur did not get along during filming. Arthur was not used to Hawks' highly improvisational style, and when Hawks wanted Arthur to play Bonnie in a much subtly sexy way (not unlike his other "Hawksian women"), Arthur flatly said, "I can't do that kind of stuff." Hawks told Arthur at the end of the shoot, "You are one of the few people I've worked with that I don't think I've helped at all. Someday you can go see what I wanted to do because I'm gonna do this character all over again." Years later Hawks returned home to find Arthur waiting for him in his driveway. She had just seen his To Have and Have Not (1944) and confessed, "I wish I'd done what you'd asked me to do. If you ever make another picture with me, I'll promise to do any goddamn thing you want to do. If a kid [Lauren Bacall] can come in and do that kind of stuff, I certainly could do it." Hawks and Arthur never collaborated again.